Epac1 è un gene codificato dal simbolo RAPGEF3. Altri nomi includono: Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI; RAPGEF3; CGEF1; EPAC. Epac1 ha una massa di 103.75kDa e una lunghezza di amminoacidi di 923.
Offriamo 10 anticorpi contro Epac1, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto e Cavallo.
Informazioni su geni e proteine
Riepilogo UniProt
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Specificità del tessuto
Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Posizione cellulare
Endomembrane system.
