eIF5A è un gene codificato dal simbolo EIF5A. Altri nomi includono: Eukaryotic translation initiation factor 5A-1; eIF-5A-1; Eukaryotic initiation factor 5A isoform 1; eIF-5A; Rev-binding factor; eIF-4D. eIF5A ha una massa di 16.83kDa e una lunghezza di amminoacidi di 154.
Offriamo 8 anticorpi contro eIF5A, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Specificità del tessuto
Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
Somiglianze di sequenza
Belongs to the eIF-5A family.
Modifica post-translazionale
Acetylated. Deacetylated by SIRT2.
Posizione cellulare
Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > Nuclear pore complex.
Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
Uso biotecnologico
Mature eIF5A-1 may be used as an in situ diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva.
