EDG4 è un gene codificato dal simbolo LPAR2. Altri nomi includono: Lysophosphatidic acid receptor 2; LPA receptor 2; Lysophosphatidic acid receptor Edg-4; LPAR2; LPA2. EDG4 ha una massa di 39.08kDa e una lunghezza di amminoacidi di 351.
Offriamo 7 anticorpi contro EDG4, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
Sommario di Entrez
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined.
Specificità del tessuto
Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
Somiglianze di sequenza
Belongs to the G-protein coupled receptor 1 family.
Posizione cellulare
Cell surface. Cell membrane.
Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
