Dopamine Transporter è un gene codificato dal simbolo SLC6A3. Altri nomi includono: Sodium-dependent DA transporter; Solute carrier family 6 member 3; SLC6A3; DAT1. Dopamine Transporter ha una massa di 68.5kDa, una lunghezza di amminoacidi di 620, ed è implicato in Parkinsonism-dystonia infantile.
Offriamo 8 anticorpi contro Dopamine Transporter, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Sommario di Entrez
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
Specificità del tessuto
Highly expressed in substantia nigra.
Coinvolgimento nella malattia
Parkinsonism-dystonia infantile: A neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs.
Somiglianze di sequenza
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
Posizione cellulare
Cell membrane.
