Dopamine Receptor D5 è un gene codificato dal simbolo DRD5. Altri nomi includono: D(1B) dopamine receptor; D(5) dopamine receptor; D1beta dopamine receptor; Dopamine D5 receptor; DRD5; DRD1B; DRD1L2. Dopamine Receptor D5 ha una massa di 52.95kDa, una lunghezza di amminoacidi di 477, ed è implicato in Benign essential blepharospasm.
Offriamo 12 anticorpi contro Dopamine Receptor D5, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Sommario di Entrez
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2.
Specificità del tessuto
Neuron-specific, localized primarily within limbic regions of the brain.
Coinvolgimento nella malattia
Benign essential blepharospasm: A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
Somiglianze di sequenza
Belongs to the G-protein coupled receptor 1 family.
Posizione cellulare
Cell membrane.
