DOK5 è un gene codificato dal simbolo DOK5. Altri nomi includono: Docking protein 5; Downstream of tyrosine kinase 5; Insulin receptor substrate 6; IRS-6; C20orf180. DOK5 ha una massa di 35.46kDa e una lunghezza di amminoacidi di 306.
Offriamo 6 anticorpi contro DOK5, allevati nel Coniglio e Capra, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Sommario di Entrez
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants.
Specificità del tessuto
Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
Somiglianze di sequenza
Belongs to the DOK family. Type B subfamily.
Modifica post-translazionale
Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
