DNA Polymerase iota è un gene codificato dal simbolo POLI. Altri nomi includono: Eta2; RAD30 homolog B; POLI; RAD30B. DNA Polymerase iota ha una massa di 83.01kDa e una lunghezza di amminoacidi di 740.
Offriamo 6 anticorpi contro DNA Polymerase iota, allevati nel Coniglio e Topo, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunogobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940).
Sommario di Entrez
The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion.
Specificità del tessuto
Ubiquitous. Highly expressed in testis.
Somiglianze di sequenza
Belongs to the DNA polymerase type-Y family.
Modifica post-translazionale
Monoubiquitinated. Protein monoubiquitination prevents POLI binding to ubiquitin via the ubiquitin-binding motif 1 and ubiquitin-binding motif 2.
Posizione cellulare
Nucleus.
Binding to ubiquitin mediates localization to replication forks after UV-induced DNA damage.
