DLK è un gene codificato dal simbolo DLK1. Altri nomi includono: Protein delta homolog 1-1; pG21. DLK ha una massa di 41.3kDa e una lunghezza di amminoacidi di 383.
Offriamo 9 anticorpi contro DLK, allevati nel Coniglio e Human, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May have a role in neuroendocrine differentiation.
Sommario di Entrez
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal.
Specificità del tessuto
Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue.
Modifica post-translazionale
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Posizione cellulare
Membrane. Cytoplasm.
