Dkk3 è un gene codificato dal simbolo DKK3. Altri nomi includono: Dickkopf-related protein 3; Dickkopf-3; REIC. Dkk3 ha una massa di 38.39kDa e una lunghezza di amminoacidi di 350.
Offriamo 11 anticorpi contro Dkk3, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Sommario di Entrez
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
Specificità del tessuto
Highest expression in heart, brain, and spinal cord.
Somiglianze di sequenza
Belongs to the dickkopf family.
Modifica post-translazionale
N- and O-glycosylated.
Posizione cellulare
Secreted.
