DHRS2 è un gene codificato dal simbolo DHRS2. Altri nomi includono: Dehydrogenase/reductase SDR family member 2, mitochondrial; Dicarbonyl reductase HEP27; Protein D; Short chain dehydrogenase/reductase family 25C member 1; SDR25C1. DHRS2 ha una massa di 29.93kDa e una lunghezza di amminoacidi di 280.
Offriamo 6 anticorpi contro DHRS2, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Sommario di Entrez
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants.
Specificità del tessuto
Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
Somiglianze di sequenza
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Posizione cellulare
Mitochondrion matrix. Nucleus.
A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
