Desmoglein 3 è un gene codificato dal simbolo DSG3. Altri nomi includono: Desmoglein-3; 130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6; DSG3; CDHF6. Desmoglein 3 ha una massa di 107.53kDa e una lunghezza di amminoacidi di 999.
Offriamo 17 anticorpi contro Desmoglein 3, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Sommario di Entrez
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris.
Specificità del tessuto
Epidermis, tongue, tonsil, esophagus and carcinomas.
Posizione cellulare
Cell membrane. Cell junction > Desmosome.
