Decorin è un gene codificato dal simbolo DCN. Altri nomi includono: Bone proteoglycan II; PG-S2; PG40; DCN; SLRR1B. Decorin ha una massa di 39.75kDa, una lunghezza di amminoacidi di 359, ed è implicato in Corneal dystrophy, congenital stromal.
Offriamo 19 anticorpi contro Decorin, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo, Ratto, Bovino, Maiale, Coniglio, Pollo e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
May affect the rate of fibrils formation.
Sommario di Entrez
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.
Coinvolgimento nella malattia
Corneal dystrophy, congenital stromal: A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
Somiglianze di sequenza
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Modifica post-translazionale
The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
Posizione cellulare
Secreted > Extracellular space > Extracellular matrix.
