DcR3 è un gene codificato dal simbolo TNFRSF6B. Altri nomi includono: Tumor necrosis factor receptor superfamily member 6B; Decoy receptor 3; Decoy receptor for Fas ligand; M68; TNFRSF6B; TR6. DcR3 ha una massa di 32.68kDa e una lunghezza di amminoacidi di 300.
Offriamo 7 anticorpi contro DcR3, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
Sommario di Entrez
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.
Specificità del tessuto
Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
Posizione cellulare
Secreted.
