DCK è un gene codificato dal simbolo DCK. Altri nomi includono: Deoxycytidine kinase; Deoxyadenosine kinase; Deoxyguanosine kinase. DCK ha una massa di 30.52kDa e una lunghezza di amminoacidi di 260.
Offriamo 12 anticorpi contro DCK, allevati nel Coniglio, Topo e Pollo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:1996353, PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:20614893). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445).
Sommario di Entrez
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
Somiglianze di sequenza
Belongs to the DCK/DGK family.
Modifica post-translazionale
Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
Posizione cellulare
Nucleus.
