Cytokeratin 8+18 è un gene codificato dal simbolo KRT8. Altri nomi includono: Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8; KRT8; CYK8. Cytokeratin 8+18 ha una massa di 53.7kDa, una lunghezza di amminoacidi di 483, ed è implicato in Cirrhosis.
Offriamo 10 anticorpi contro Cytokeratin 8+18, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Sommario di Entrez
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
Specificità del tessuto
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Coinvolgimento nella malattia
Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Somiglianze di sequenza
Belongs to the intermediate filament family.
Modifica post-translazionale
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
Posizione cellulare
Cytoplasm. Nucleus > Nucleoplasm. Nucleus matrix.
