Cytokeratin 5 + 8 è un gene codificato dal simbolo KRT8. Altri nomi includono: Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8; KRT8; CYK8. Cytokeratin 5 + 8 ha una massa di 53.7kDa, una lunghezza di amminoacidi di 483, ed è implicato in Cirrhosis.
Offriamo 7 anticorpi contro Cytokeratin 5 + 8, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo, Ratto, Bovino, Maiale, Coniglio, Pecora, Cane, Gatto, Furetto e Criceto.
Informazioni su geni e proteine
Riepilogo UniProt
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Sommario di Entrez
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Specificità del tessuto
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Coinvolgimento nella malattia
Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Somiglianze di sequenza
Belongs to the intermediate filament family.
Modifica post-translazionale
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
Posizione cellulare
Cytoplasm. Nucleus > Nucleoplasm. Nucleus matrix.
