Cyclophilin F è un gene codificato dal simbolo PPIF. Altri nomi includono: Peptidyl-prolyl cis-trans isomerase F, mitochondrial; PPIase F; Cyclophilin D; CyP-D; Mitochondrial cyclophilin; CyP-M; Rotamase F; PPIF; CYP3. Cyclophilin F ha una massa di 22.04kDa e una lunghezza di amminoacidi di 207.
Offriamo 6 anticorpi contro Cyclophilin F, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Sommario di Entrez
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.
Somiglianze di sequenza
Belongs to the cyclophilin-type PPIase family.
Modifica post-translazionale
Deacetylated at Lys-167 by SIRT3.
Posizione cellulare
Mitochondrion matrix.
