Cyclin E1 è un gene codificato dal simbolo CCNE1. Altri nomi includono: G1/S-specific cyclin-E1; CCNE1; CCNE. Cyclin E1 ha una massa di 47.08kDa e una lunghezza di amminoacidi di 410.
Offriamo 25 anticorpi contro Cyclin E1, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Essential for the control of the cell cycle at the G1/S (start) transition.
Sommario di Entrez
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
Specificità del tessuto
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Somiglianze di sequenza
Belongs to the cyclin family. Cyclin E subfamily.
Modifica post-translazionale
Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
Posizione cellulare
Nucleus.
