Cyclin C è un gene codificato dal simbolo CCNC. Altri nomi includono: Cyclin-C; SRB11 homolog; hSRB11; CCNC. Cyclin C ha una massa di 33.24kDa e una lunghezza di amminoacidi di 283.
Offriamo 9 anticorpi contro Cyclin C, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Sommario di Entrez
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Somiglianze di sequenza
Belongs to the cyclin family. Cyclin C subfamily.
Posizione cellulare
Nucleus.
