Cyclin A2 è un gene codificato dal simbolo CCNA2. Altri nomi includono: Cyclin-A2; Cyclin-A; Cyclin A; CCNA2; CCN1; CCNA. Cyclin A2 ha una massa di 48.55kDa e una lunghezza di amminoacidi di 432.
Offriamo 8 anticorpi contro Cyclin A2, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto e Bovino.
Informazioni su geni e proteine
Riepilogo UniProt
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Sommario di Entrez
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M.
Somiglianze di sequenza
Belongs to the cyclin family. Cyclin AB subfamily.
Modifica post-translazionale
Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
Posizione cellulare
Nucleus. Cytoplasm.
Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606).
