CtBP1 è un gene codificato dal simbolo CTBP1. Altri nomi includono: C-terminal-binding protein 1; CTBP. CtBP1 ha una massa di 47.54kDa, una lunghezza di amminoacidi di 440, ed è implicato in Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome.
Offriamo 15 anticorpi contro CtBP1, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e ChIP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
Sommario di Entrez
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
Specificità del tessuto
Expressed in germinal center B-cells.
Coinvolgimento nella malattia
Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome: An autosomal dominant disorder characterized by delayed motor development, intellectual disability, failure to thrive, hypotonia, ataxia, and tooth enamel defects.
Somiglianze di sequenza
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Modifica post-translazionale
The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
Posizione cellulare
Cytoplasm. Nucleus.
