Crk p38 è un gene codificato dal simbolo CRK. Altri nomi includono: Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK. Crk p38 ha una massa di 33.83kDa e una lunghezza di amminoacidi di 304.
Offriamo 10 anticorpi contro Crk p38, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto, Coniglio, Scimmia e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.
Sommario di Entrez
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Somiglianze di sequenza
Belongs to the CRK family.
Modifica post-translazionale
Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway (PubMed:17515907). Isoform Crk-II: Phosphorylated by KIT (By similarity).
Posizione cellulare
Cytoplasm. Cell membrane.
Translocated to the plasma membrane upon cell adhesion.
