CREM è un gene codificato dal simbolo CREM. Altri nomi includono: cAMP-responsive element modulator; Inducible cAMP early repressor; ICER. CREM ha una massa di 37.01kDa e una lunghezza di amminoacidi di 345.
Offriamo 6 anticorpi contro CREM, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
Sommario di Entrez
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
Specificità del tessuto
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Somiglianze di sequenza
Belongs to the bZIP family.
Modifica post-translazionale
Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Posizione cellulare
Nucleus.
