CRABP2 è un gene codificato dal simbolo CRABP2. Altri nomi includono: Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II. CRABP2 ha una massa di 15.69kDa e una lunghezza di amminoacidi di 138.
Offriamo 10 anticorpi contro CRABP2, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e ChIP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Sommario di Entrez
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Somiglianze di sequenza
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Modifica post-translazionale
Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
Posizione cellulare
Cytoplasm. Endoplasmic reticulum. Nucleus.
Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
