Corticotropin Releasing Factor è un gene codificato dal simbolo CRH. Altri nomi includono: Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone; CRH. Corticotropin Releasing Factor ha una massa di 21.42kDa e una lunghezza di amminoacidi di 196.
Offriamo 9 anticorpi contro Corticotropin Releasing Factor, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).
Sommario di Entrez
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
Specificità del tessuto
Produced by the hypothalamus and placenta.
Somiglianze di sequenza
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Posizione cellulare
Secreted.