Claudin 7 è un gene codificato dal simbolo CLDN7. Altri nomi includono: Claudin-7; CLDN-7; CLDN7; CEPTRL2; CPETRL2. Claudin 7 ha una massa di 22.42kDa e una lunghezza di amminoacidi di 211.
Offriamo 12 anticorpi contro Claudin 7, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Plays a major role in tight junction-specific obliteration of the intercellular space.
Sommario di Entrez
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.
Specificità del tessuto
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Somiglianze di sequenza
Belongs to the claudin family.
Modifica post-translazionale
Phosphorylated.
Posizione cellulare
Cell membrane. Basolateral cell membrane. Cell junction > Tight junction.
Co-localizes with EPCAM at the basolateral cell membrane and tight junction.
