Claudin 6 è un gene codificato dal simbolo CLDN6. Altri nomi includono: Claudin-6; Skullin; CLDN6. Claudin 6 ha una massa di 23.29kDa e una lunghezza di amminoacidi di 220.
Offriamo 13 anticorpi contro Claudin 6, allevati nel Coniglio e Human, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Plays a major role in tight junction-specific obliteration of the intercellular space.
Sommario di Entrez
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
Specificità del tessuto
Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
Somiglianze di sequenza
Belongs to the claudin family.
Posizione cellulare
Cell junction > Tight junction. Cell membrane.
