Claudin 4 è un gene codificato dal simbolo CLDN4. Altri nomi includono: Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; Williams-Beuren syndrome chromosomal region 8 protein; CLDN4; CPER; CPETR1; WBSCR8. Claudin 4 ha una massa di 22.08kDa e una lunghezza di amminoacidi di 209.
Offriamo 12 anticorpi contro Claudin 4, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Sommario di Entrez
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
Somiglianze di sequenza
Belongs to the claudin family.
Modifica post-translazionale
Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
Posizione cellulare
Cell junction > Tight junction. Cell membrane.
CLDN4 is required for tight junction localization in the kidney.
