Clathrin light chain è un gene codificato dal simbolo CLTA. Altri nomi includono: Clathrin light chain A; Lca; CLTA. Clathrin light chain ha una massa di 27.08kDa e una lunghezza di amminoacidi di 248.
Offriamo 9 anticorpi contro Clathrin light chain, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).
Sommario di Entrez
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12.
Somiglianze di sequenza
Belongs to the clathrin light chain family.
Posizione cellulare
Cytoplasmic vesicle membrane. Membrane > Coated pit. Cytoplasm > Cytoskeleton > Spindle.
Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.
