CES2 è un gene codificato dal simbolo CES2. Altri nomi includono: Cocaine esterase; Carboxylesterase 2; CE-2; Methylumbelliferyl-acetate deacetylase 2; ICE. CES2 ha una massa di 61.81kDa e una lunghezza di amminoacidi di 559.
Offriamo 6 anticorpi contro CES2, allevati nel Coniglio, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).
Sommario di Entrez
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.
Specificità del tessuto
Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
Somiglianze di sequenza
Belongs to the type-B carboxylesterase/lipase family.
Modifica post-translazionale
Glycosylated.
Posizione cellulare
Endoplasmic reticulum lumen.
