Cela3b è un gene codificato dal simbolo CELA3B. Altri nomi includono: Chymotrypsin-like elastase family member 3B; Elastase IIIB; Elastase-3B; Protease E; ELA3B. Cela3b ha una massa di 29.26kDa e una lunghezza di amminoacidi di 270.
Offriamo 18 anticorpi contro Cela3b, allevati nel Coniglio e Topo, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Efficient protease with alanine specificity but only little elastolytic activity.
Sommario di Entrez
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
Specificità del tessuto
Pancreas. Not detectable in keratinocytes.
Somiglianze di sequenza
Belongs to the peptidase S1 family. Elastase subfamily.
