Cdc6 è un gene codificato dal simbolo CDC6. Altri nomi includono: Cell division control protein 6 homolog-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC18L. Cdc6 ha una massa di 62.72kDa, una lunghezza di amminoacidi di 560, ed è implicato in Meier-Gorlin syndrome 5.
Offriamo 10 anticorpi contro Cdc6, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e ChIP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Sommario di Entrez
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
Coinvolgimento nella malattia
Meier-Gorlin syndrome 5: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
Somiglianze di sequenza
Belongs to the CDC6/cdc18 family.
Posizione cellulare
Nucleus. Cytoplasm.
The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895).
