CDC5L è un gene codificato dal simbolo CDC5L. Altri nomi includono: Cell division cycle 5-like protein; Cdc5-like protein; Pombe cdc5-related protein; KIAA0432; PCDC5RP. CDC5L ha una massa di 92.25kDa e una lunghezza di amminoacidi di 802.
Offriamo 6 anticorpi contro CDC5L, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811).
Sommario di Entrez
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.
Specificità del tessuto
Ubiquitously expressed in both fetal and adult tissues.
Somiglianze di sequenza
Belongs to the CEF1 family.
Modifica post-translazionale
Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8.
Posizione cellulare
Nucleus. Nucleus speckle. Cytoplasm.
May shuttle between cytoplasm and nucleus.
