Cdc37 è un gene codificato dal simbolo CDC37. Altri nomi includono: Hsp90 co-chaperone Hsp90 chaperone protein kinase-targeting subunit; p50CDC37A. Cdc37 ha una massa di 44.47kDa e una lunghezza di amminoacidi di 378.
Offriamo 14 anticorpi contro Cdc37, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto e S. cerevisiae.
Informazioni su geni e proteine
Riepilogo UniProt
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
Sommario di Entrez
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
Somiglianze di sequenza
Belongs to the CDC37 family.
Modifica post-translazionale
Constitutively sumoylated by UBE2I.
Posizione cellulare
Cytoplasm.
