CD73 è un gene codificato dal simbolo NT5E. Altri nomi includono: 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; NT5E; NT5; NTE. CD73 ha una massa di 63.37kDa, una lunghezza di amminoacidi di 574, ed è implicato in Calcification of joints and arteries.
Offriamo 33 anticorpi contro CD73, allevati nel Coniglio, Topo e Human, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo, Ratto e Primati.
Informazioni su geni e proteine
Riepilogo UniProt
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.
Sommario di Entrez
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.
Coinvolgimento nella malattia
Calcification of joints and arteries: A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands.
Somiglianze di sequenza
Belongs to the 5'-nucleotidase family.
Posizione cellulare
Cell membrane.
