Anticorpi CD59

43 prodotti

CD59 è un gene codificato dal simbolo CD59. Altri nomi includono: CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; MIC11; MIN1; MIN2; MIN3; MSK21. CD59 ha una massa di 14.18kDa, una lunghezza di amminoacidi di 128, ed è implicato in Hemolytic anemia, CD59-mediated, with or without polyneuropathy.

Offriamo 43 anticorpi contro CD59, allevati nel Coniglio, Topo, Ratto e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati ​​da Umano, Topo, Ratto e Maiale.

Informazioni su geni e proteine

Riepilogo UniProt
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
Sommario di Entrez
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Coinvolgimento nella malattia
Hemolytic anemia, CD59-mediated, with or without polyneuropathy: An autosomal recessive disorder characterized by infantile onset of chronic hemolysis and a relapsing-remitting polyneuropathy, often exacerbated by infection, and manifested as hypotonia, limb muscle weakness, and hyporeflexia.
Modifica post-translazionale
N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine. Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.
Posizione cellulare
Cell membrane. Secreted.

Soluble form found in a number of tissues.
Collegamenti al database
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Visualizza prodotto10µg Dimensione di prova
Western Blot - Anti-CD59 Antibody [MEM-43/5] (A85694) - Antibodies.com
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Flow Cytometry - Anti-CD59 Antibody [MEM-43] (FITC) (A85983) - Antibodies.com
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Western Blot - Anti-CD59 Antibody [ARC0896] (A305532) - Antibodies.com
(3)
Flow Cytometry - Anti-CD59 Antibody [MEM-43] (Biotin) (A85991) - Antibodies.com
Western Blot - Anti-CD59 Antibody (A11470) - Antibodies.com
(3)
Flow Cytometry - Anti-CD59 Antibody [MEM-43] (PE) (A85985) - Antibodies.com
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SDS-PAGE - Anti-CD59 Antibody [Research Grade Biosimilar] - Low endotoxin, Azide free (A323950) - Antibodies.com
(2)
Visualizza prodottoAnticorpo ricombinante
Immunohistochemistry - Anti-CD59 Antibody [MACIF/629] - BSA and Azide free (A253920) - Antibodies.com
(2)
Immunohistochemistry - Anti-CD59 Antibody [MACIF/629] (A250740) - Antibodies.com
(2)
Western Blot - Anti-CD59 Antibody (C30369) - Antibodies.com
(4)
Visualizza prodotto10µg Dimensione di prova
SDS-PAGE - Anti-CD59 Antibody [Research Grade Biosimilar] - Low endotoxin, Azide free (A323951) - Antibodies.com
(2)
Visualizza prodottoAnticorpo ricombinante
Immunohistochemistry - Anti-CD59 Antibody [SPM616] (A250740) - Antibodies.com
Immunohistochemistry - Anti-CD59 Antibody [193-27] - BSA and Azide free (A254356) - Antibodies.com
(2)
Immunohistochemistry - Anti-CD59 Antibody [193-27] (A251079) - Antibodies.com
(2)
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Immunohistochemistry - Anti-CD59 Antibody [SPM616] - BSA and Azide free (A253920) - Antibodies.com
SDS-PAGE - Anti-CD59 Antibody [BRA-10G] (A250738) - Antibodies.com
SDS-PAGE - Anti-CD59 Antibody [BRA-10G] - BSA and Azide free (A253918) - Antibodies.com
Western Blot - Anti-CD59 Antibody (A88316) - Antibodies.com
Immunohistochemistry - Anti-CD59 Antibody [MACIF/2867R] (A250741) - Antibodies.com
(2)
Visualizza prodottoAnticorpo ricombinante
Flow Cytometry - Anti-CD59 Antibody [MEM-43] (APC) (A85982) - Antibodies.com
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Immunohistochemistry - Anti-CD59 Antibody [MACIF/2867R] - BSA and Azide free (A253921) - Antibodies.com
(2)
Visualizza prodottoAnticorpo ricombinante
Immunohistochemistry - Anti-CD59 Antibody [MACIF/1193] - BSA and Azide free (A254356) - Antibodies.com
SDS-PAGE - Anti-CD59 Antibody [MACIF/7021R] - BSA and Azide free (A278689) - Antibodies.com
Visualizza prodottoAnticorpo ricombinante
Immunohistochemistry - Anti-CD59 Antibody [MACIF/1193] (A251079) - Antibodies.com
SDS-PAGE - Anti-CD59 Antibody [MACIF/7021R] (A278101) - Antibodies.com
Visualizza prodottoAnticorpo ricombinante
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Western Blot - Anti-CD59 Antibody [ARC56723] (A309320) - Antibodies.com
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Visualizza prodottoAnticorpo ricombinante
CD59 Monoclonal Antibody from Signalway Antibody (42018) - Antibodies.com
(3)
Anti-CD59 Antibody from Bioworld Technology (BS6553) - Antibodies.com
Immunohistochemistry - CD59 glycoprotein Polyclonal Antibody from Signalway Antibody (42110) - Antibodies.com
(2)
Western blot - CD59 Polyclonal Antibody from Signalway Antibody (41659) - Antibodies.com
Western blot - CD59 Antibody from Signalway Antibody (32388) - Antibodies.com

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