CD39 è un gene codificato dal simbolo ENTPD1. Altri nomi includono: Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-apyrase; Lymphoid cell activation antigen; ENTPD1. CD39 ha una massa di 57.97kDa, una lunghezza di amminoacidi di 510, ed è implicato in Spastic paraplegia 64, autosomal recessive.
Offriamo 27 anticorpi contro CD39, allevati nel Coniglio, Topo, Ratto e Human, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Sommario di Entrez
The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only.
Coinvolgimento nella malattia
Spastic paraplegia 64, autosomal recessive: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Somiglianze di sequenza
Belongs to the GDA1/CD39 NTPase family.
Modifica post-translazionale
The N-terminus is blocked.
Posizione cellulare
Membrane.
