CD27 è un gene codificato dal simbolo CD27. Altri nomi includono: CD27 antigenL receptor; T-cell activation antigen T14; Tumor necrosis factor receptor superfamily member 7; TNFRSF7. CD27 ha una massa di 29.14kDa, una lunghezza di amminoacidi di 260, ed è implicato in Lymphoproliferative syndrome 2.
Offriamo 58 anticorpi contro CD27, allevati nel Coniglio, Topo, Capra, Criceto e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto e Maiale.
Informazioni su geni e proteine
Riepilogo UniProt
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Sommario di Entrez
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Specificità del tessuto
Found in most T-lymphocytes.
Coinvolgimento nella malattia
Lymphoproliferative syndrome 2: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
Modifica post-translazionale
Phosphorylated.
Posizione cellulare
Membrane.
