CD20 è un gene codificato dal simbolo MS4A1. Altri nomi includono: B-lymphocyte antigen B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; MS4A1. CD20 ha una massa di 33.08kDa, una lunghezza di amminoacidi di 297, ed è implicato in Immunodeficiency, common variable, 5.
Offriamo 108 anticorpi contro CD20, allevati nel Coniglio, Topo, Capra e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso, IP e ChIP con campioni derivati da Umano, Topo, Ratto, Bovino, Scimmia, Cane e Primati.
Informazioni su geni e proteine
Riepilogo UniProt
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602).
Sommario di Entrez
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Specificità del tessuto
Expressed on B-cells.
Coinvolgimento nella malattia
Immunodeficiency, common variable, 5: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Somiglianze di sequenza
Belongs to the MS4A family.
Modifica post-translazionale
Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.
Posizione cellulare
Cell membrane. Cell membrane.
Constitutively associated with membrane rafts.
