CD1b è un gene codificato dal simbolo CD1B. È noto anche come T-cell surface glycoprotein CD1B. CD1b ha una massa di 36.94kDa e una lunghezza di amminoacidi di 333.
Offriamo 13 anticorpi contro CD1b, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Sommario di Entrez
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.
Specificità del tessuto
Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Posizione cellulare
Cell membrane. Endosome membrane. Lysosome membrane.
Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.
