CD16 è un gene codificato dal simbolo FCGR3A. Altri nomi includono: Low affinity immunoglobulin gamma Fc region receptor III-Aa antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; FcR-10; IgG Fc receptor III-2; FCGR3AA; FCG3; FCGR3; IGFR3. CD16 ha una massa di 29.09kDa, una lunghezza di amminoacidi di 254, ed è implicato in Immunodeficiency 20.
Offriamo 51 anticorpi contro CD16, allevati nel Coniglio, Topo e Ratto, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Bovino, Maiale, Pecora, Gatto e Primati.
Informazioni su geni e proteine
Riepilogo UniProt
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Sommario di Entrez
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.
Coinvolgimento nella malattia
Immunodeficiency 20: A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV).
Modifica post-translazionale
Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
Posizione cellulare
Cell membrane. Secreted.
Exists also as a soluble receptor.
