CD153 è un gene codificato dal simbolo TNFSF8. Altri nomi includono: Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L; TNFSF8; CD30L; CD30LG. CD153 ha una massa di 26.02kDa e una lunghezza di amminoacidi di 234.
Offriamo 7 anticorpi contro CD153, allevati nel Coniglio, che sono adatti per WB, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
Sommario di Entrez
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
Somiglianze di sequenza
Belongs to the tumor necrosis factor family.
Posizione cellulare
Membrane.
