CD137 è un gene codificato dal simbolo TNFRSF9. Altri nomi includono: Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNFRSF9; ILA. CD137 ha una massa di 27.9kDa e una lunghezza di amminoacidi di 255.
Offriamo 36 anticorpi contro CD137, allevati nel Coniglio, Topo, Capra, Ratto, Criceto e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto e Primati.
Informazioni su geni e proteine
Riepilogo UniProt
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Sommario di Entrez
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Specificità del tessuto
Expressed on the surface of activated T-cells.
Posizione cellulare
Membrane.
