CD11c è un gene codificato dal simbolo ITGAX. Altri nomi includono: Integrin alpha-X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; ITGAX. CD11c ha una massa di 127.83kDa e una lunghezza di amminoacidi di 1163.
Offriamo 33 anticorpi contro CD11c, allevati nel Coniglio, Topo e Criceto, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Bovino, Scimmia, Pecora, Cane, Goat e Raccoon.
Informazioni su geni e proteine
Riepilogo UniProt
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Sommario di Entrez
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Predominantly expressed in monocytes and granulocytes.
Somiglianze di sequenza
Belongs to the integrin alpha chain family.
Posizione cellulare
Membrane.
