CCR4 è un gene codificato dal simbolo CCR4. Altri nomi includono: C-C chemokine receptor type 4; C-C CKR-4; K5-5; CMKBR4. CCR4 ha una massa di 41.4kDa e una lunghezza di amminoacidi di 360.
Offriamo 15 anticorpi contro CCR4, allevati nel Coniglio, Capra e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso, IP e Dot con campioni derivati da Umano, Topo, Ratto, Scimmia e Gatto.
Informazioni su geni e proteine
Riepilogo UniProt
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Sommario di Entrez
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
Specificità del tessuto
Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
Somiglianze di sequenza
Belongs to the G-protein coupled receptor 1 family.
Modifica post-translazionale
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Posizione cellulare
Cell membrane.
