Calpastatin è un gene codificato dal simbolo CAST. Altri nomi includono: Calpain inhibitor; Sperm BS-17 component; CAST. Calpastatin ha una massa di 76.57kDa, una lunghezza di amminoacidi di 708, ed è implicato in Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads.
Offriamo 6 anticorpi contro Calpastatin, allevati nel Coniglio e Topo, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Sommario di Entrez
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
Coinvolgimento nella malattia
Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads: An autosomal recessive disease characterized by generalized, continuous shedding of the outer layers of the epidermis, leukonychia, acral punctate keratosis, cheilitis, knuckle pads with multiple hyperkeratotic micropapules involving the interphalangeal joints, and palmoplantar keratoderma.
Somiglianze di sequenza
Belongs to the protease inhibitor I27 (calpastatin) family.
Modifica post-translazionale
The N-terminus is blocked.
