Anticorpi CAD

6 prodotti

CAD è un gene codificato dal simbolo CAD. È noto anche come CAD protein. CAD ha una massa di 242.98kDa, una lunghezza di amminoacidi di 2225, ed è implicato in Epileptic encephalopathy, early infantile, 50.

Offriamo 6 anticorpi contro CAD, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Sommario di Entrez
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.
Coinvolgimento nella malattia
Epileptic encephalopathy, early infantile, 50: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE50 is an autosomal recessive, progressive disease with onset in infancy and favorable response to treatment with oral uridine.
Somiglianze di sequenza
In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
Modifica post-translazionale
Activated by MAP kinase (Erk1/2) phosphorylation just prior to the S phase of the cell cycle, when the demand for pyrimidine nucleotides is greatest, and down-regulated as the cells emerge from S phase by protein kinase A (PKA) phosphorylation. Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity. Phosphorylation at Ser-1406 reduces sensitivity to feedback inhibition by UTP.
Posizione cellulare
Cytoplasm. Nucleus.

Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
Collegamenti al database
Immunohistochemistry - Anti-CAD Antibody (B8308) - Antibodies.com
Visualizza prodotto10µg Dimensione di prova
Immunohistochemistry - Anti-CAD (phospho Thr456) Antibody (A8308) - Antibodies.com
Visualizza prodotto10µg Dimensione di prova
Western blot - CAD Antibody from Signalway Antibody (24037) - Antibodies.com
(2)
Western blot - CAD Antibody from Signalway Antibody (24038) - Antibodies.com
(2)
CAD antibody from Signalway Antibody (22935) - Antibodies.com
(2)
Immunohistochemistry - CAD (Phospho-Thr456) Antibody from Signalway Antibody (11789) - Antibodies.com

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