C5R1 è un gene codificato dal simbolo C5AR1. Altri nomi includono: C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5AR1; C5AR. C5R1 ha una massa di 39.34kDa e una lunghezza di amminoacidi di 350.
Offriamo 25 anticorpi contro C5R1, allevati nel Coniglio, Topo, Capra, Ratto e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Bovino, Coniglio e Furetto.
Informazioni su geni e proteine
Riepilogo UniProt
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
Somiglianze di sequenza
Belongs to the G-protein coupled receptor 1 family.
Modifica post-translazionale
Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042).
Posizione cellulare
Cell membrane. Cytoplasmic vesicle.
Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
