Anticorpi C3

8 prodotti

C3 è un gene codificato dal simbolo C3. Altri nomi includono: Complement C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; CPAMD1. C3 ha una massa di 187.15kDa, una lunghezza di amminoacidi di 1663, ed è implicato nella malattia: Complement component 3 deficiency; Macular degeneration, age-related, 9; Hemolytic uremic syndrome atypical 5.

Offriamo 8 anticorpi contro C3, allevati nel Coniglio, Topo, Capra e Human, che sono adatti per WB, IHC e ELISA con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
Sommario di Entrez
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.
Specificità del tessuto
Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods.
Coinvolgimento nella malattia
Complement component 3 deficiency: A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis.

Macular degeneration, age-related, 9: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

Hemolytic uremic syndrome atypical 5: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
Modifica post-translazionale
C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin and dietary chylomicrons.
Posizione cellulare
Secreted.
SDS-PAGE - Anti-C3 Antibody [NGM621] - Low endotoxin, Azide free (A323909) - Antibodies.com
Visualizza prodottoAnticorpo ricombinante
Immunohistochemistry - Anti-C3 Antibody (A286077) - Antibodies.com
(2)
Western Blot - Anti-C3 Antibody [ARC56851] (A308585) - Antibodies.com
(2)
Western Blot - Anti-C3 Antibody (A93154) - Antibodies.com
Segnaposto immagine Antibodies.com - Scopri di più spendendo meno
Western Blot - Anti-C3 Antibody [ARC0541] (A306105) - Antibodies.com
Segnaposto immagine Antibodies.com - Scopri di più spendendo meno
Segnaposto immagine Antibodies.com - Scopri di più spendendo meno

Mostra 1-8 di 8 prodotti

Filtri Menù Principale Contattaci 0Check-out
Inizio pagina