C14orf166 è un gene codificato dal simbolo RTRAF. Altri nomi includono: RNA transcription, translation and transport factor protein; CLE7 homolog; CLE; RTRAF. C14orf166 ha una massa di 28.07kDa e una lunghezza di amminoacidi di 244.
Offriamo 7 anticorpi contro C14orf166, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ICC/IF e ChIP con campioni derivati da Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264).
Specificità del tessuto
Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors.
Somiglianze di sequenza
Belongs to the RTRAF family.
Posizione cellulare
Nucleus. Cytoplasm > Cytosol. Cytoplasm > Perinuclear region. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.
May localize at the centrosome during mitosis (PubMed:15147888). Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264).
